Here’s five things to expect…
1) Goals at Anfield
Arsenal travel to Anfield top of the table and unbeaten in the last six games, over which they’ve picked up five wins, while their current record against Liverpool will also fill Arsene Wenger with confidence, given that the Gunners have lost once in their last 12 games against Liverpool.
Saturday’s early kick-off marks the beginning of a incredibly testing and demanding run for the Gunners, one which will go a long way in determining their success this season and against Liverpool, Arsene Wenger could be reminded of what he missed out in the summer by not signing Luis Suarez.
The Uruguayan will lead the line yet again, as Liverpool look to strengthen their fourth spot and continue their impressive home form, which has seen them winning eight out of the last nine.
Were Arsenal to win, they’d have to be considered a lot more seriously than they’ve been so far, but even a draw wouldn’t be a disaster for Arsene Wenger’s men.
Above all, though, expect goals and entertainment as Liverpool have scored at least two goals in their last nine at Anfield, while Arsenal have found net at least twice in their last five games on the road.
2) AJ to shine again
Forget about the likes of Suarez and Aguero, the Premier League’s in-form player at the moment plies his trade for Sunderland and has been instrumental in dragging them away from the bottom of the table.
Adam Johnson has six goals and two assists in the last four Premier League games and with Sunderland hosting Hull on Saturday, the former Manchester City man could prove crucial for the Wearsiders yet again.
Sunderland have won three in the last four but remain just two points above the relegation zone and Gus Poyet will need Johnson to shine against Hull if his side are to put themselves more distance between them and the bottom three.
3) Roy’s watching
Southampton are undoubtedly one of the success stories of the season. Mauricio Pochettino’s men have shown that sensible business in the transfer window and the right football philosophy can still pay-off in modern day football and the Saints have proved those who had deemed them a flash in the pan wrong, as they sit in ninth place.
A large part of Southampton’s success this season is undoubtedly down to Adam Lallana, who looks to be edging closer and closer to clinch a spot in the England squad for the World Cup.
Having scored three in the last four, the 25-year-old is, along with Adam Johnson, one of the in-form players in the Premier League and, best of all as far as Roy Hodgson is concerned, he’s English.
Expect the England manager to be keeping a close eye on Lallana as Southampton take on Stoke this weekend.
4) What next for Fulham?
Five defeats in the last six Premier League games with just three goals scored over those fixtures and now out of the FA Cup after an embarrassing performance on Tuesday, Fulham are, quite simply, a mess.
Luckily for them, they travel to Old Trafford to face a Manchester United whose problems under David Moyes seem to grow bigger each week, but even the current beleaguered United side could prove too much for Rene’ Meulensteen, as the Dutchman returns to Old Trafford for the first time since leaving in the summer.
Obviously, Kostas Mitroglou might hit the ground running and prove us all wrong, but the Cottagers look to be heading for the Championship.
5) D-Day in Wales
As if the second instalment of the first ever Welsh derby in the Premier League wasn’t going to be explosive enough, both clubs arrive into Saturday’s showdown having replaced their managers since they first met.
If Malky Mackay’s departure was expected, Michael Laudrup’s came as more of a surprise, for Swansea, despite their poor form, still seem too good to go down, or at least too good for the other eight teams embroiled in the fight to avoid relegation.
Whether Laudrup’s sacking will prove to be the kick in the teeth Swansea players needed to get going remains to be seen, while having picked up their first league win in five games, Cardiff will have an added motivation to get one over their rivals.
A win for Ole Gunnar Solskjaer’s men would put them level with Swansea, another turn in this season’s ever changing relegation scrap.